Journal: Investigative Ophthalmology & Visual Science
Article Title: High-Dose Sucralose Is Associated With Lacrimal Circadian Remodeling, Reduced Immunometabolic Signatures, and Reduced Tear Secretion
doi: 10.1167/iovs.67.5.11
Figure Lengend Snippet: Ocular surface functional readouts after 30 days SUC exposure. ( A ) Phenol red thread test is used to measure tear secretion in mice. ( B ) Tear secretion (mm) assessed by phenol-red thread test (20 seconds) 10 minutes after pilocarpine-HCl 4.5 mg/kg; per-animal value is the mean of both eyes. Two-way ANOVA was used for intergroup and intra group comparisons, and one-way ANOVA was used for comparisons among different time points within each group. * P < 0.05, *** P < 0.001.
Article Snippet: After 10 minutes, a sterile phenol red thread (Cat. No. 30059010; Tianjin Jingming New Technology Development Co., Tianjin, China) was gently placed in the inferior conjunctival fornix at the medial canthus for 20 seconds.
Techniques: Functional Assay